Učitavanje...
Unregulated antigen-presenting cell activation by T cells breaks self tolerance
T cells proliferate vigorously following acute depletion of CD4(+) Foxp3(+) T regulatory cells [natural Tregs (nTregs)] and also when naive T cells are transferred to syngeneic, nTreg-deficient Rag1(−/−) hosts. Here, using mice raised in an antigen-free (AF) environment, we show that proliferation i...
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| Izdano u: | Proc Natl Acad Sci U S A |
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| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6338877/ https://ncbi.nlm.nih.gov/pubmed/30598454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818624116 |
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