Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance

We have developed a model of autoimmunity to investigate autoantibody-mediated cross-presentation of self antigen. RIP-mOVA mice, expressing OVA in pancreatic β cells, develop severe autoimmune diabetes when given OT-I cells (OVA-specific CD8(+) T cells) and anti-OVA IgG but not when given T cells a...

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Main Authors: Harbers, Stephanie O., Crocker, Andrea, Catalano, Geoffrey, D’Agati, Vivette, Jung, Steffen, Desai, Dharmesh D., Clynes, Raphael
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1849985/
https://ncbi.nlm.nih.gov/pubmed/17446931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29470
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