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Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes
Type I interferon (IFN) is a critical mediator of autoimmune diseases such as systemic lupus erythematosus (SLE) and Aicardi–Goutières Syndrome (AGS). The recently discovered cyclic-GMP-AMP (cGAMP) synthase (cGAS) induces the production of type I IFN in response to cytosolic DNA and is potentially l...
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| Vydáno v: | Eur J Immunol |
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| Hlavní autoři: | , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6386451/ https://ncbi.nlm.nih.gov/pubmed/29215161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201747338 |
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