Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes

Type I interferon (IFN) is a critical mediator of autoimmune diseases such as systemic lupus erythematosus (SLE) and Aicardi–Goutières Syndrome (AGS). The recently discovered cyclic-GMP-AMP (cGAMP) synthase (cGAS) induces the production of type I IFN in response to cytosolic DNA and is potentially l...

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Detalhes bibliográficos
Publicado no:Eur J Immunol
Main Authors: Steinhagen, Folkert, Zillinger, Thomas, Peukert, Konrad, Fox, Mario, Thudium, Marcus, Barchet, Winfried, Putensen, Christian, Klinman, Dennis, Latz, Eicke, Bode, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6386451/
https://ncbi.nlm.nih.gov/pubmed/29215161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201747338
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