Synthetic Oligodeoxynucleotides (ODN) Containing Suppressive TTAGGG Motifs Inhibit AIM2 Inflammasome Activation

Synthetic oligodeoxynucleotides comprised of the immunosuppressive motif TTAGGG block TLR9 signaling, prevent STAT1 and STAT4 phosphorylation and attenuate a variety of inflammatory responses in vivo. Here, we demonstrate that such suppressive oligodeoxynucleotides (sup ODN) abrogate activation of c...

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Main Authors: Kaminski, John J., Schattgen, Stefan A., Tzeng, Te-Chen, Bode, Christian, Klinman, Dennis M., Fitzgerald, Katherine A.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3878640/
https://ncbi.nlm.nih.gov/pubmed/23986531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300530
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