Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants

Live attenuated vaccines (LAVs), if sufficiently safe, provide the most potent and durable anti-pathogen responses in vaccinees with single immunizations commonly yielding lifelong immunity. Historically, viral LAVs were derived by blind passage of virulent strains in cultured cells resulting in ada...

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Udgivet i:PLoS Pathog
Main Authors: Trobaugh, Derek W., Sun, Chengqun, Dunn, Matthew D., Reed, Douglas S., Klimstra, William B.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6386422/
https://ncbi.nlm.nih.gov/pubmed/30742691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007584
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