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Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants
Live attenuated vaccines (LAVs), if sufficiently safe, provide the most potent and durable anti-pathogen responses in vaccinees with single immunizations commonly yielding lifelong immunity. Historically, viral LAVs were derived by blind passage of virulent strains in cultured cells resulting in ada...
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| Pubblicato in: | PLoS Pathog |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6386422/ https://ncbi.nlm.nih.gov/pubmed/30742691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007584 |
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