Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca(2+)/calmodulin kinase II constitutive phosphorylation of ryanodine receptors

AIMS: Abnormal Ca(2+) release from the sarcoplasmic reticulum (SR), associated with Ca(2+)-calmodulin kinase II (CaMKII)-dependent phosphorylation of RyR2 at Ser2814, has consistently been linked to arrhythmogenesis and ischaemia/reperfusion (I/R)-induced cell death. In contrast, the role played by...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Valverde, Carlos A, Mazzocchi, Gabriela, Di Carlo, Mariano N, Ciocci Pardo, Alejandro, Salas, Nehuen, Ragone, María Ines, Felice, Juan I, Cely-Ortiz, Alejandra, Consolini, Alicia E, Portiansky, Enrique, Mosca, Susana, Kranias, Evangelia G, Wehrens, Xander H T, Mattiazzi, Alicia
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6383052/
https://ncbi.nlm.nih.gov/pubmed/30169578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvy213
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