PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection

By engulfing potentially harmful microbes, professional phagocytes are continually at risk from intracellular pathogens. To avoid becoming infected, the host must kill pathogens in the phagosome before they can escape or establish a survival niche. Here, we analyse the role of the phosphoinositide (...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Buckley, Catherine M., Heath, Victoria L., Guého, Aurélie, Bosmani, Cristina, Knobloch, Paulina, Sikakana, Phumzile, Personnic, Nicolas, Dove, Stephen K., Michell, Robert H., Meier, Roger, Hilbi, Hubert, Soldati, Thierry, Insall, Robert H., King, Jason S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6382210/
https://ncbi.nlm.nih.gov/pubmed/30730983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007551
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