PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection

By engulfing potentially harmful microbes, professional phagocytes are continually at risk from intracellular pathogens. To avoid becoming infected, the host must kill pathogens in the phagosome before they can escape or establish a survival niche. Here, we analyse the role of the phosphoinositide (...

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Vydáno v:PLoS Pathog
Hlavní autoři: Buckley, Catherine M., Heath, Victoria L., Guého, Aurélie, Bosmani, Cristina, Knobloch, Paulina, Sikakana, Phumzile, Personnic, Nicolas, Dove, Stephen K., Michell, Robert H., Meier, Roger, Hilbi, Hubert, Soldati, Thierry, Insall, Robert H., King, Jason S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6382210/
https://ncbi.nlm.nih.gov/pubmed/30730983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007551
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