PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection

By engulfing potentially harmful microbes, professional phagocytes are continually at risk from intracellular pathogens. To avoid becoming infected, the host must kill pathogens in the phagosome before they can escape or establish a survival niche. Here, we analyse the role of the phosphoinositide (...

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Опубликовано в: :PLoS Pathog
Главные авторы: Buckley, Catherine M., Heath, Victoria L., Guého, Aurélie, Bosmani, Cristina, Knobloch, Paulina, Sikakana, Phumzile, Personnic, Nicolas, Dove, Stephen K., Michell, Robert H., Meier, Roger, Hilbi, Hubert, Soldati, Thierry, Insall, Robert H., King, Jason S.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2019
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6382210/
https://ncbi.nlm.nih.gov/pubmed/30730983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007551
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