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Precision medicine review: rare driver mutations and their biophysical classification

How can biophysical principles help precision medicine identify rare driver mutations? A major tenet of pragmatic approaches to precision oncology and pharmacology is that driver mutations are very frequent. However, frequency is a statistical attribute, not a mechanistic one. Rare mutations can als...

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Detalhes bibliográficos
Publicado no:Biophys Rev
Main Authors: Nussinov, Ruth, Jang, Hyunbum, Tsai, Chung-Jung, Cheng, Feixiong
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6381362/
https://ncbi.nlm.nih.gov/pubmed/30610579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12551-018-0496-2
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