Effective binding to protein antigens by antibodies from antibody libraries designed with enhanced protein recognition propensities

Antibodies provide immune protection by recognizing antigens of diverse chemical properties, but elucidating the amino acid sequence-function relationships underlying the specificity and affinity of antibody-antigen interactions remains challenging. We designed and constructed phage-displayed synthe...

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Veröffentlicht in:MAbs
Hauptverfasser: Jian, Jhih-Wei, Chen, Hong-Sen, Chiu, Yi-Kai, Peng, Hung-Pin, Tung, Chao-Ping, Chen, Ing-Chien, Yu, Chung-Ming, Tsou, Yueh-Liang, Kuo, Wei-Ying, Hsu, Hung-Ju, Yang, An-Suei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380391/
https://ncbi.nlm.nih.gov/pubmed/30526270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1550320
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