PD-1 blockade potentiates HIV latency reversal ex vivo in CD4(+) T cells from ART-suppressed individuals

HIV persists in latently infected CD4(+) T cells during antiretroviral therapy (ART). Immune checkpoint molecules, including PD-1, are preferentially expressed at the surface of persistently infected cells. However, whether PD-1 plays a functional role in HIV latency and reservoir persistence remain...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Fromentin, Rémi, DaFonseca, Sandrina, Costiniuk, Cecilia T., El-Far, Mohamed, Procopio, Francesco Andrea, Hecht, Frederick M., Hoh, Rebecca, Deeks, Steven G., Hazuda, Daria J., Lewin, Sharon R., Routy, Jean-Pierre, Sékaly, Rafick-Pierre, Chomont, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379401/
https://ncbi.nlm.nih.gov/pubmed/30778080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08798-7
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