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Homozygous c.359del variant in MGME1 is associated with early onset cerebellar ataxia

We ascertained a child with early onset cerebellar ataxia and identified a novel frameshift deletion, c.359del [p. (Pro120Leufs*2), NM_052865.2] in exon 2 of MGME1 (mitochondrial genome maintenance exonuclease 1) by exome sequencing. Variations in MGME1 have been reported to cause mitochondrial DNA...

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Bibliografiska uppgifter
I publikationen:Eur J Med Genet
Huvudupphovsmän: Hebbar, Malavika, Girisha, Katta M., Srivastava, Anshika, Bielas, Stephanie, Shukla, Anju
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379073/
https://ncbi.nlm.nih.gov/pubmed/28711739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmg.2017.07.010
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