Conformation‐specific antibodies against multiple amyloid protofibril species from a single amyloid immunogen

We engineered and employed a chaperone‐like amyloid‐binding protein Nucleobindin 1 (NUCB1) to stabilize human islet amyloid polypeptide (hIAPP) protofibrils for use as immunogen in mice. We obtained multiple monoclonal antibody (mAb) clones that were reactive against hIAPP protofibrils. A secondary...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Bonito‐Oliva, Alessandra, Schedin‐Weiss, Sophia, Younesi, Shahab S., Tiiman, Ann, Adura, Carolina, Paknejad, Navid, Brendel, Matt, Romin, Yevgeniy, Parchem, Ronald J., Graff, Caroline, Vukojević, Vladana, Tjernberg, Lars O., Terenius, Lars, Winblad, Bengt, Sakmar, Thomas P., Graham, W Vallen
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6378190/
https://ncbi.nlm.nih.gov/pubmed/30663210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14119
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