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Nucleobindin 1 Caps Human Islet Amyloid Polypeptide Protofibrils to Prevent Amyloid Fibril Formation
Many human diseases are associated with amyloid fibril deposition, including type 2 diabetes mellitus (DM) where human Islet Amyloid Polypeptide (hIAPP) forms fibrils in the pancreas. We report here that engineered, soluble forms of the human Ca(2+)-binding protein Nucleobindin 1 (NUCB1), prevent hI...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3398247/ https://ncbi.nlm.nih.gov/pubmed/22542527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.04.017 |
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