Nucleobindin 1 Caps Human Islet Amyloid Polypeptide Protofibrils to Prevent Amyloid Fibril Formation

Many human diseases are associated with amyloid fibril deposition, including type 2 diabetes mellitus (DM) where human Islet Amyloid Polypeptide (hIAPP) forms fibrils in the pancreas. We report here that engineered, soluble forms of the human Ca(2+)-binding protein Nucleobindin 1 (NUCB1), prevent hI...

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Hlavní autoři: Gupta, Ruchi, Kapoor, Neeraj, Raleigh, Daniel P., Sakmar, Thomas P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398247/
https://ncbi.nlm.nih.gov/pubmed/22542527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.04.017
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