Akt methylation by SETDB1 promotes Akt kinase activity and oncogenic functions

Aberrant activation of Akt disturbs proliferation, survival and metabolic homeostasis of various human cancers. Thus, it is critical to understand upstream signaling pathways governing Akt activation. Here, we report that Akt undergoes SETDB1-mediated lysine-methylation to promote its activation, wh...

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Veröffentlicht in:Nat Cell Biol
Hauptverfasser: Guo, Jianping, Dai, Xiangpeng, Laurent, Benoit, Zheng, Nana, Gan, Wenjian, Zhang, Jian, Guo, Ailan, Yuan, Min, Liu, Pengda, Asara, John M., Toker, Alex, Shi, Yang, Pandolfi, Pier Paolo, Wei, Wenyi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6377565/
https://ncbi.nlm.nih.gov/pubmed/30692625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0261-6
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