Akt-mediated Phosphorylation of XLF Impairs Non-homologous End Joining DNA Repair

Deficiency in repair of damaged DNA leads to genomic instability and is closely associated with tumorigenesis. Most DNA double-strand-breaks (DSBs) are repaired by two major mechanisms, homologous-recombination (HR) and non-homologous-end-joining (NHEJ). Although Akt has been reported to suppress HR...

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Publicado no:Mol Cell
Main Authors: Liu, Pengda, Gan, Wenjian, Guo, Chunguang, Xie, Anyong, Gao, Daming, Guo, Jianping, Zhang, Jinfang, Willis, Nicholas, Su, Arthur, Asara, John M., Scully, Ralph, Wei, Wenyi
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336609/
https://ncbi.nlm.nih.gov/pubmed/25661488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.01.005
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