Akt methylation by SETDB1 promotes Akt kinase activity and oncogenic functions

Aberrant activation of Akt disturbs proliferation, survival and metabolic homeostasis of various human cancers. Thus, it is critical to understand upstream signaling pathways governing Akt activation. Here, we report that Akt undergoes SETDB1-mediated lysine-methylation to promote its activation, wh...

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Detalhes bibliográficos
Publicado no:Nat Cell Biol
Main Authors: Guo, Jianping, Dai, Xiangpeng, Laurent, Benoit, Zheng, Nana, Gan, Wenjian, Zhang, Jian, Guo, Ailan, Yuan, Min, Liu, Pengda, Asara, John M., Toker, Alex, Shi, Yang, Pandolfi, Pier Paolo, Wei, Wenyi
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6377565/
https://ncbi.nlm.nih.gov/pubmed/30692625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0261-6
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