Akt methylation by SETDB1 promotes Akt kinase activity and oncogenic functions

Aberrant activation of Akt disturbs proliferation, survival and metabolic homeostasis of various human cancers. Thus, it is critical to understand upstream signaling pathways governing Akt activation. Here, we report that Akt undergoes SETDB1-mediated lysine-methylation to promote its activation, wh...

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發表在:Nat Cell Biol
Main Authors: Guo, Jianping, Dai, Xiangpeng, Laurent, Benoit, Zheng, Nana, Gan, Wenjian, Zhang, Jian, Guo, Ailan, Yuan, Min, Liu, Pengda, Asara, John M., Toker, Alex, Shi, Yang, Pandolfi, Pier Paolo, Wei, Wenyi
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6377565/
https://ncbi.nlm.nih.gov/pubmed/30692625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0261-6
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