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Torsional stress generated by ADF/cofilin on cross-linked actin filaments boosts their severing

Proteins of the actin depolymerizing factor (ADF)/cofilin family are the central regulators of actin filament disassembly. A key function of ADF/cofilin is to sever actin filaments. However, how it does so in a physiological context, where filaments are interconnected and under mechanical stress, re...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wioland, Hugo, Jegou, Antoine, Romet-Lemonne, Guillaume
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6377502/
https://ncbi.nlm.nih.gov/pubmed/30692249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1812053116
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