ADF/Cofilin Accelerates Actin Dynamics by Severing Filaments and Promoting Their Depolymerization at Both Ends

Actin-depolymerizing factor (ADF)/cofilins contribute to cytoskeletal dynamics by promoting rapid actin filament disassembly. In the classical view, ADF/cofilin sever filaments, and capping proteins block filament barbed ends whereas pointed ends depolymerize, at a rate that is still debated. Here,...

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Vydáno v:Curr Biol
Hlavní autoři: Wioland, Hugo, Guichard, Berengere, Senju, Yosuke, Myram, Sarah, Lappalainen, Pekka, Jégou, Antoine, Romet-Lemonne, Guillaume
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505867/
https://ncbi.nlm.nih.gov/pubmed/28625781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2017.05.048
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