Common Coding Variants in SCN10A are associated with the Nav1.8 Late Current and Cardiac Conduction

BACKGROUND. Genetic variants at the SCN5A/SCN10A locus are strongly associated with electrocardiographic PR and QRS intervals. While SCN5A is the canonical cardiac sodium channel gene, the role of SCN10A in cardiac conduction is less well characterized. METHODS AND RESULTS. We sequenced the SCN10A l...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Circ Genom Precis Med
Main Authors: Macri, Vincenzo, Brody, Jennifer A., Arking, Dan E., Hucker, William J., Yin, Xiaoyan, Lin, Honghuang, Mills, Robert W., Sinner, Moritz F., Lubitz, Steven A., Liu, Ching-Ti, Morrison, Alanna C., Alonso, Alvaro, Li, Ning, Fedorov, Vadim V., Janssen, Paul M., Bis, Joshua C., Heckbert, Susan R., Dolmatova, Elena V., Lumley, Thomas, Sitlani, Colleen M., Cupples, L. Adrienne, Pulit, Sara L., Newton-Cheh, Christopher, Barnard, John, Smith, Jonathan D., Van Wagoner, David R., Chung, Mina K., Vlahakes, Gus J., O’Donnell, Christopher J., Rotter, Jerome I., Margulies, Kenneth B., Morley, Michael P., Cappola, Thomas P., Benjamin, Emelia J., Muzny, Donna M., Gibbs, Richard A., Jackson, Rebecca D., Magnani, Jared W., Herndon, Caroline N., Rich, Stephen S., Psaty, Bruce M., Milan, David J., Boerwinkle, Eric, Mohler, Peter J., Sotoodehnia, Nona, Ellinor, Patrick T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6377236/
https://ncbi.nlm.nih.gov/pubmed/29752399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGEN.116.001663
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados