Common Coding Variants in SCN10A are associated with the Nav1.8 Late Current and Cardiac Conduction

BACKGROUND. Genetic variants at the SCN5A/SCN10A locus are strongly associated with electrocardiographic PR and QRS intervals. While SCN5A is the canonical cardiac sodium channel gene, the role of SCN10A in cardiac conduction is less well characterized. METHODS AND RESULTS. We sequenced the SCN10A l...

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Publicado en:Circ Genom Precis Med
Autores principales: Macri, Vincenzo, Brody, Jennifer A., Arking, Dan E., Hucker, William J., Yin, Xiaoyan, Lin, Honghuang, Mills, Robert W., Sinner, Moritz F., Lubitz, Steven A., Liu, Ching-Ti, Morrison, Alanna C., Alonso, Alvaro, Li, Ning, Fedorov, Vadim V., Janssen, Paul M., Bis, Joshua C., Heckbert, Susan R., Dolmatova, Elena V., Lumley, Thomas, Sitlani, Colleen M., Cupples, L. Adrienne, Pulit, Sara L., Newton-Cheh, Christopher, Barnard, John, Smith, Jonathan D., Van Wagoner, David R., Chung, Mina K., Vlahakes, Gus J., O’Donnell, Christopher J., Rotter, Jerome I., Margulies, Kenneth B., Morley, Michael P., Cappola, Thomas P., Benjamin, Emelia J., Muzny, Donna M., Gibbs, Richard A., Jackson, Rebecca D., Magnani, Jared W., Herndon, Caroline N., Rich, Stephen S., Psaty, Bruce M., Milan, David J., Boerwinkle, Eric, Mohler, Peter J., Sotoodehnia, Nona, Ellinor, Patrick T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6377236/
https://ncbi.nlm.nih.gov/pubmed/29752399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGEN.116.001663
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