Diminished PRRX1 Expression is Associated with Increased Risk of Atrial Fibrillation and Shortening of the Cardiac Action Potential

BACKGROUND: Atrial fibrillation (AF) affects over 33 million individuals worldwide. Genome-wide association studies have identified at least 30 AF loci, but the mechanisms through which individual variants lead to altered disease risk have remained unclear for the majority of these loci. At the 1q24...

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Pubblicato in:Circ Cardiovasc Genet
Autori principali: Tucker, Nathan R., Dolmatova, Elena V., Lin, Honghuang, Cooper, Rebecca R., Ye, Jiangchuan, Hucker, William J., Jameson, Heather S., Parsons, Victoria A., Weng, Lu Chen, Mills, Robert W., Sinner, Moritz F., Imakaev, Maxim, Leyton-Mange, Jordan, Vlahakes, Gus, Benjamin, Emelia J., Lunetta, Kathryn L., Lubitz, Steven A., Mirny, Leonid, Milan, David J., Ellinor, Patrick T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679717/
https://ncbi.nlm.nih.gov/pubmed/28974514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.117.001902
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