Sequencing of SCN5A identifies rare and common variants associated with cardiac conduction

BACKGROUND: The cardiac sodium channel SCN5A regulates atrioventricular and ventricular conduction. Genetic variants in this gene are associated with PR and QRS intervals. We sought to further characterize the contribution of rare and common coding variation in SCN5A to cardiac conduction. METHODS A...

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Detalhes bibliográficos
Main Authors: Magnani, Jared W., Brody, Jennifer A., Prins, Bram P., Arking, Dan E., Lin, Honghuang, Yin, Xiaoyan, Liu, Ching-Ti, Morrison, Alanna C., Zhang, Feng, Spector, Tim D., Alonso, Alvaro, Bis, Joshua C., Heckbert, Susan R., Lumley, Thomas, Sitlani, Colleen M., Cupples, L. Adrienne, Lubitz, Steven A., Soliman, Elsayed Z., Pulit, Sara L., Newton-Cheh, Christopher, O'Donnell, Christopher J., Ellinor, Patrick T., Benjamin, Emelia J., Muzny, Donna M., Gibbs, Richard A., Santibanez, Jireh, Taylor, Herman A., Rotter, Jerome I., Lange, Leslie A., Psaty, Bruce M., Jackson, Rebecca, Rich, Stephen S., Boerwinkle, Eric, Jamshidi, Yalda, Sotoodehnia, Nona
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177904/
https://ncbi.nlm.nih.gov/pubmed/24951663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.113.000098
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