Pharmacogenetics and pharmacokinetics of CNS penetration of efavirenz and its metabolites

BACKGROUND: There are limited data on the pharmacogenetics and pharmacokinetics of the CNS penetration of efavirenz. OBJECTIVES: We investigated genetic polymorphisms associated with CSF concentrations of efavirenz and its metabolites and explored the relationships with neurocognitive performance. M...

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Publicado en:J Antimicrob Chemother
Autores principales: Decloedt, Eric H, Sinxadi, Phumla Z, van Zyl, Gert U, Wiesner, Lubbe, Khoo, Saye, Joska, John A, Haas, David W, Maartens, Gary
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2019
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6376850/
https://ncbi.nlm.nih.gov/pubmed/30535366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dky481
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