Pharmacogenetics of plasma efavirenz exposure in HIV-infected adults and children in South Africa

AIMS: Genetic factors, notably CYP2B6 516G→T [rs3745274] and 983T→C [rs28399499], explain much of the interindividual variability in efavirenz pharmacokinetics, but data from Africa are limited. We characterized relationships between genetic polymorphisms and plasma efavirenz concentrations in HIV-i...

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Bibliografske podrobnosti
izdano v:Br J Clin Pharmacol
Main Authors: Sinxadi, Phumla Z, Leger, Paul D, McIlleron, Helen M, Smith, Peter J, Dave, Joel A, Levitt, Naomi S, Maartens, Gary, Haas, David W
Format: Artigo
Jezik:Inglês
Izdano: John Wiley & Sons, Ltd 2015
Teme:
Pharmacogenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500334/
https://ncbi.nlm.nih.gov/pubmed/25611810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12590
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