Pharmacokinetic and pharmacogenetic associations with dolutegravir neuropsychiatric adverse events in an African population

BACKGROUND: Dolutegravir has been associated with neuropsychiatric adverse events (NPAEs), but relationships between dolutegravir concentrations and NPAEs are unclear. OBJECTIVES: To determine in an African population whether a concentration–response relationship exists between dolutegravir and trea...

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Bibliografiske detaljer
Udgivet i:J Antimicrob Chemother
Main Authors: Griesel, Rulan, Sinxadi, Phumla, Kawuma, Aida, Joska, John, Sokhela, Simiso, Akpomiemie, Godspower, Venter, Francois, Denti, Paolo, Haas, David W, Maartens, Gary
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2022
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613765/
https://ncbi.nlm.nih.gov/pubmed/36031789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkac290
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