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Bacterial killing by complement requires membrane attack complex formation via surface‐bound C5 convertases

The immune system kills bacteria by the formation of lytic membrane attack complexes (MACs), triggered when complement enzymes cleave C5. At present, it is not understood how the MAC perturbs the composite cell envelope of Gram‐negative bacteria. Here, we show that the role of C5 convertase enzymes...

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Bibliografske podrobnosti
izdano v:EMBO J
Main Authors: Heesterbeek, Dani AC, Bardoel, Bart W, Parsons, Edward S, Bennett, Isabel, Ruyken, Maartje, Doorduijn, Dennis J, Gorham, Ronald D, Berends, Evelien TM, Pyne, Alice LB, Hoogenboom, Bart W, Rooijakkers, Suzan HM
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6376327/
https://ncbi.nlm.nih.gov/pubmed/30643019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899852
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