Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models

Complement is essential for the protection against infections; however, dysregulation of complement activation can cause onset and progression of numerous inflammatory diseases. Convertase enzymes play a central role in complement activation and produce the key mediators of complement: C3 convertase...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Zwarthoff, Seline A., Berends, Evelien T. M., Mol, Sanne, Ruyken, Maartje, Aerts, Piet C., Józsi, Mihály, de Haas, Carla J. C., Rooijakkers, Suzan H. M., Gorham, Ronald D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064732/
https://ncbi.nlm.nih.gov/pubmed/30083158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01691
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