Bacterial killing by complement requires direct anchoring of membrane attack complex precursor C5b-7

An important effector function of the human complement system is to directly kill Gram-negative bacteria via Membrane Attack Complex (MAC) pores. MAC pores are assembled when surface-bound convertase enzymes convert C5 into C5b, which together with C6, C7, C8 and multiple copies of C9 forms a transm...

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Publicat a:PLoS Pathog
Autors principals: Doorduijn, Dennis J., Bardoel, Bart W., Heesterbeek, Dani A. C., Ruyken, Maartje, Benn, Georgina, Parsons, Edward S., Hoogenboom, Bart W., Rooijakkers, Suzan H. M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351214/
https://ncbi.nlm.nih.gov/pubmed/32569291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008606
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