Carbonic anhydrase is not a relevant nitrite reductase or nitrous anhydrase in the lung

KEY POINTS: Carbonic anhydrase (CA) inhibitors such as acetazolamide inhibit hypoxic pulmonary vasoconstriction (HPV) in humans and other mammals, but the mechanism of this action remains unknown. It has been postulated that carbonic anhydrase may act as a nitrous anhydrase in vivo to generate nitri...

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Veröffentlicht in:J Physiol
Hauptverfasser: Pickerodt, Philipp A., Kronfeldt, Sebastian, Russ, Martin, Gonzalez‐Lopez, Adrian, Lother, Philipp, Steiner, Elvira, Vorbrodt, Katja, Busch, Thilo, Boemke, Willehad, Francis, Roland C. E., Swenson, Erik R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Reviews and Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6376076/
https://ncbi.nlm.nih.gov/pubmed/29660141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP275894
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