Pulmonary vasodilation by acetazolamide during hypoxia: impact of methyl-group substitutions and administration route in conscious, spontaneously breathing dogs

Acetazolamide (ACZ) prevents hypoxic pulmonary vasoconstriction (HPV) in isolated lungs, animals, and humans, but not by carbonic anhydrase (CA) inhibition. We studied administration routes in, and certain structural aspects of, ACZ critical to HPV inhibition. Analogs of ACZ during acute hypoxia wer...

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Detalhes bibliográficos
Main Authors: Pickerodt, Philipp A., Francis, Roland C., Höhne, Claudia, Neubert, Friederike, Telalbasic, Stella, Boemke, Willehad, Swenson, Erik R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972746/
https://ncbi.nlm.nih.gov/pubmed/24481964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.01235.2013
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