Lens differentiation is controlled by the balance between PDGF and FGF signaling

How multiple receptor tyrosine kinases coordinate cell fate determination is yet to be elucidated. We show here that the receptor for platelet-derived growth factor (PDGF) signaling recruits the p85 subunit of Phosphoinositide 3-kinase (PI3K) to regulate mammalian lens development. Activation of PI3...

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Bibliografiske detaljer
Udgivet i:PLoS Biol
Main Authors: Li, Hongge, Mao, Yingyu, Bouaziz, Michael, Yu, Honglian, Qu, Xiuxia, Wang, Fen, Feng, Gen-Sheng, Shawber, Carrie, Zhang, Xin
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6375662/
https://ncbi.nlm.nih.gov/pubmed/30716082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000133
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