Lens differentiation is controlled by the balance between PDGF and FGF signaling

How multiple receptor tyrosine kinases coordinate cell fate determination is yet to be elucidated. We show here that the receptor for platelet-derived growth factor (PDGF) signaling recruits the p85 subunit of Phosphoinositide 3-kinase (PI3K) to regulate mammalian lens development. Activation of PI3...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Li, Hongge, Mao, Yingyu, Bouaziz, Michael, Yu, Honglian, Qu, Xiuxia, Wang, Fen, Feng, Gen-Sheng, Shawber, Carrie, Zhang, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6375662/
https://ncbi.nlm.nih.gov/pubmed/30716082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000133
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