Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα

Fucoidans are sulfated fucose-based polysaccharides that activate platelets and have pro- and anticoagulant effects; thus, they may have therapeutic value. In the present study, we show that 2 synthetic sulfated α-l-fucoside-pendant glycopolymers (with average monomeric units of 13 and 329) and natu...

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Detalles Bibliográficos
Publicado en:Blood Adv
Autores principales: Kardeby, Caroline, Fälker, Knut, Haining, Elizabeth J., Criel, Maarten, Lindkvist, Madelene, Barroso, Ruben, Påhlsson, Peter, Ljungberg, Liza U., Tengdelius, Mattias, Rainger, G. Ed, Watson, Stephanie, Eble, Johannes A., Hoylaerts, Marc F., Emsley, Jonas, Konradsson, Peter, Watson, Steve P., Sun, Yi, Grenegård, Magnus
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2019
Materias:
Platelets and Thrombopoiesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6373755/
https://ncbi.nlm.nih.gov/pubmed/30700416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018024950
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