Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbβ and a GPIbβ/GPIX chimera

Platelet GPIb-IX receptor complex has 3 subunits GPIbα, GPIbβ, and GPIX, which assemble with a ratio of 1:2:1. Dysfunction in surface expression of the complex leads to Bernard-Soulier syndrome. We have crystallized the GPIbβ ectodomain (GPIbβ(E)) and determined the structure to show a single leucin...

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Detalhes bibliográficos
Main Authors: McEwan, Paul A., Yang, Wenjun, Carr, Katherine H., Mo, Xi, Zheng, Xiaofeng, Li, Renhao, Emsley, Jonas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217411/
https://ncbi.nlm.nih.gov/pubmed/21908432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-05-356253
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