Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons

The insulin/insulin-like growth factor 1 (IGF1) signaling pathways are implicated in longevity and in progression of Alzheimer’s disease. Previously, we showed that insulin-like growth factor 1 receptor (IGF1R) and downstream signaling transcripts are reduced in astrocytes in human brain with progre...

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Publicado no:Neuroscience
Main Authors: Ratcliffe, Laura E., Vázquez Villaseñor, Irina, Jennings, Luke, Heath, Paul R., Mortiboys, Heather, Schwartzentruber, Aurelie, Karyka, Evangelia, Simpson, Julie E., Ince, Paul G., Garwood, Claire J., Wharton, Stephen B.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372003/
https://ncbi.nlm.nih.gov/pubmed/30056117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2018.07.029
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