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Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

BACKGROUND: The insulin/IGF1 signalling (IIS) pathways are involved in longevity regulation and are dysregulated in neurons in Alzheimer’s disease (AD). We previously showed downregulation in IIS gene expression in astrocytes with AD-neuropathology progression, but IIS in astrocytes remains poorly u...

詳細記述

保存先:
書誌詳細
出版年:Mol Brain
主要な著者: Garwood, Claire J., Ratcliffe, Laura E., Morgan, Sarah V., Simpson, Julie E., Owens, Helen, Vazquez-Villaseñor, Irina, Heath, Paul R., Romero, Ignacio A., Ince, Paul G., Wharton, Stephen B.
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546315/
https://ncbi.nlm.nih.gov/pubmed/26297026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-015-0138-6
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