Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

BACKGROUND: The insulin/IGF1 signalling (IIS) pathways are involved in longevity regulation and are dysregulated in neurons in Alzheimer’s disease (AD). We previously showed downregulation in IIS gene expression in astrocytes with AD-neuropathology progression, but IIS in astrocytes remains poorly u...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Brain
Main Authors: Garwood, Claire J., Ratcliffe, Laura E., Morgan, Sarah V., Simpson, Julie E., Owens, Helen, Vazquez-Villaseñor, Irina, Heath, Paul R., Romero, Ignacio A., Ince, Paul G., Wharton, Stephen B.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546315/
https://ncbi.nlm.nih.gov/pubmed/26297026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-015-0138-6
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados