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NADP(+) is an endogenous PARP inhibitor in DNA damage response and tumor suppression
ADP-ribosylation is a unique posttranslational modification catalyzed by poly(ADP-ribose) polymerases (PARPs) using NAD(+) as ADP-ribose donor. PARPs play an indispensable role in DNA damage repair and small molecule PARP inhibitors have emerged as potent anticancer drugs. However, to date, PARP inh...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6370829/ https://ncbi.nlm.nih.gov/pubmed/30741937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08530-5 |
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