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miR-25 alleviates polyQ-mediated cytotoxicity by silencing ATXN3
MicroRNAs (miRNAs) have been reported to play significant roles in the pathogenesis of various polyQ diseases. This study aims to investigate the regulation of ATXN3 gene expression by miRNA. We found that miR-25 reduced both wild-type and polyQ-expanded mutant ataxin-3 protein levels by interacting...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | FEBS Lett |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6370487/ https://ncbi.nlm.nih.gov/pubmed/25451224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2014.11.013 |
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