miR-25 alleviates polyQ-mediated cytotoxicity by silencing ATXN3

MicroRNAs (miRNAs) have been reported to play significant roles in the pathogenesis of various polyQ diseases. This study aims to investigate the regulation of ATXN3 gene expression by miRNA. We found that miR-25 reduced both wild-type and polyQ-expanded mutant ataxin-3 protein levels by interacting...

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Detalhes bibliográficos
Publicado no:FEBS Lett
Main Authors: Huang, Fengzhen, Zhang, Li, Long, Zhe, Chen, Zhao, Hou, Xuan, Wang, Chunrong, Peng, Huirong, Wang, Junling, Li, Jiada, Duan, Ranhui, Xia, Kun, Chuang, De-Maw, Tang, Beisha, Jiang, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370487/
https://ncbi.nlm.nih.gov/pubmed/25451224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2014.11.013
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