miR-25 alleviates polyQ-mediated cytotoxicity by silencing ATXN3

MicroRNAs (miRNAs) have been reported to play significant roles in the pathogenesis of various polyQ diseases. This study aims to investigate the regulation of ATXN3 gene expression by miRNA. We found that miR-25 reduced both wild-type and polyQ-expanded mutant ataxin-3 protein levels by interacting...

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Pubblicato in:FEBS Lett
Autori principali: Huang, Fengzhen, Zhang, Li, Long, Zhe, Chen, Zhao, Hou, Xuan, Wang, Chunrong, Peng, Huirong, Wang, Junling, Li, Jiada, Duan, Ranhui, Xia, Kun, Chuang, De-Maw, Tang, Beisha, Jiang, Hong
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370487/
https://ncbi.nlm.nih.gov/pubmed/25451224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2014.11.013
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