Discovery and optimization of inhibitors of the Parkinson’s disease associated protein DJ-1

DJ-1 is a Parkinson’s disease associated protein endowed with enzymatic, redox sensing, regulatory, chaperoning, and neuroprotective activities. Although DJ-1 has been vigorously studied for the last decade and a half, its exact role in the progression of the disease remains uncertain. In addition,...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Tashiro, Shinya, Caaveiro, Jose M. M., Nakakido, Makoto, Tanabe, Aki, Nagatoishi, Satoru, Tamura, Yasushi, Matsuda, Noriyuki, Liu, Dali, Hoang, Quyen Q., Tsumoto, Kouhei
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370461/
https://ncbi.nlm.nih.gov/pubmed/30063823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00701
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