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Quantitative ubiquitylome analysis and crosstalk with proteome/acetylome analysis identified novel pathways and targets of perifosine treatment in neuroblastoma

BACKGROUND: Perifosine, is a third generation alkylphospholipid analog which has promising anti-tumor efficacy in clinical trials of refractory/recurrent neuroblastoma (NB). However, perifosine’s mechanism of action remains unclear. Previously, we have shown that perifosine changes global proteome a...

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Bibliographische Detailangaben
Veröffentlicht in:Transl Cancer Res
Hauptverfasser: Jiang, Min, Hua, Zhongyan, Dong, Yudi, Liu, Zhihui, Thiele, Carol J., Li, Zhijie
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370305/
https://ncbi.nlm.nih.gov/pubmed/30761266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/tcr.2018.11.30
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