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Perifosine-induced inhibition of Akt attenuates BDNF/TrkB-induced chemoresistance in neuroblastoma in vivo
BACKGROUND: Neuroblastoma (NB) tumors expressing high levels of brain-derived neurotrophic factor (BDNF) and its receptor TrkB, or activated Akt are associated with decreased event-free or overall survival in neuroblastoma patients. The effect of perifosine, an Akt inhibitor, on chemo-sensitivity of...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3158972/ https://ncbi.nlm.nih.gov/pubmed/21590687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.26133 |
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