Stromal-derived interleukin 6 drives epithelial-to-mesenchymal transition and therapy resistance in esophageal adenocarcinoma

Esophageal adenocarcinoma (EAC) has a dismal prognosis, and survival benefits of recent multimodality treatments remain small. Cancer-associated fibroblasts (CAFs) are known to contribute to poor outcome by conferring therapy resistance to various cancer types, but this has not been explored in EAC....

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ebbing, Eva A., van der Zalm, Amber P., Steins, Anne, Creemers, Aafke, Hermsen, Simone, Rentenaar, Rosa, Klein, Michelle, Waasdorp, Cynthia, Hooijer, Gerrit K. J., Meijer, Sybren L., Krishnadath, Kausilia K., Punt, Cornelis J. A., van Berge Henegouwen, Mark I., Gisbertz, Suzanne S., van Delden, Otto M., Hulshof, Maarten C. C. M., Medema, Jan Paul, van Laarhoven, Hanneke W. M., Bijlsma, Maarten F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6369811/
https://ncbi.nlm.nih.gov/pubmed/30670657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1820459116
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