Stromal-derived interleukin 6 drives epithelial-to-mesenchymal transition and therapy resistance in esophageal adenocarcinoma

Esophageal adenocarcinoma (EAC) has a dismal prognosis, and survival benefits of recent multimodality treatments remain small. Cancer-associated fibroblasts (CAFs) are known to contribute to poor outcome by conferring therapy resistance to various cancer types, but this has not been explored in EAC....

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發表在:Proc Natl Acad Sci U S A
Main Authors: Ebbing, Eva A., van der Zalm, Amber P., Steins, Anne, Creemers, Aafke, Hermsen, Simone, Rentenaar, Rosa, Klein, Michelle, Waasdorp, Cynthia, Hooijer, Gerrit K. J., Meijer, Sybren L., Krishnadath, Kausilia K., Punt, Cornelis J. A., van Berge Henegouwen, Mark I., Gisbertz, Suzanne S., van Delden, Otto M., Hulshof, Maarten C. C. M., Medema, Jan Paul, van Laarhoven, Hanneke W. M., Bijlsma, Maarten F.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2019
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6369811/
https://ncbi.nlm.nih.gov/pubmed/30670657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1820459116
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