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Cytochrome b(5) enhances androgen synthesis by rapidly reducing the CYP17A1 oxy-complex in the lyase step
Cytochrome P450 17A1 (CYP17A1) catalyzes the synthesis of androgens from the steroid precursors pregnenolone and progesterone in a two-step reaction process: allylic hydroxylation and carbo-carbon bond scission. Cytochrome b(5) (Cyt-b(5)) is a stimulator of the second lyase reaction, but the chemica...
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| Vydáno v: | FEBS Lett |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6369587/ https://ncbi.nlm.nih.gov/pubmed/29888793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.13153 |
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